What is the sequence and time course of molecular events that cause irreversible cardiovascular and neurologic dysfunction during and after cardiac arrest?
Is intra-arrest therapeutic hypothermia feasible during CPR, and does it improve outcomes?
Epinephrine is the primary drug that is used in resuscitation but observational studies and a few small RCT suggest that it improves short term but not long term outcomes. Factors such as timing, dose, quality fo CPR and post-resuscitation care all confound the issue. Large RCTs conducted at multiple centers are desperately needed to address this question.
As VF/VT rates continue to decrease in cardiac arrest to levels below 25%, the importance of understanding the pathways and epidemiology of PEA gains public health importance. Additionally, there is a need to determine the co-morbidities and/or pharmacologic agents that contribute to the causation of this rhythm.
Can surveillance systems be developed to prevent in-hospital cardiac arrest outside the ICU?
What is the best way to train the public to recognize sudden cardiac arrest, perform CPR and utilize an AED?
Should out-of-hospital cardiac arrest care be regionalized to specialized centers similar to trauma, STEMI, and stroke?
Which, if any, pharmacologic and non-pharmacologic therapies are useful and effective in cardiac arrest due to non-shockable rhythms?
What is the optimal dose and duration of post-cardiac arrest hypothermic targeted temperature management?
Vascular access is a challenge in the setting of out-of-hospital cardiac arrest (OHCA). The failure of medications to impact outcomes may be in part related to the delay in drug delivery from the IV route. EMS systems have adopted intraosseous (IO) access but it is not clear if these are affecting outcome and there has been no large RCT. The current IO access devices are expensive and use different routes (sternal, tibia, ...more »
Can techniques to monitor brain injury and recovery in post-cardiac arrest patients be developed to optimize post-cardiac arrest care and enable reliable neuroprognostication?
Can improved catheters, pumps and oxygenators for extracorporeal cardiopulmonary resuscitation be developed that will make feasible widespread implementation for refractory in-hospital and out-of-hospital cardiac arrest?