Goal 2: Reduce Human Disease

Submitted by (@bldbuddy)

How should platelet (PLT) transfusions be used to treat active bleeding?

Multiple randomized controlled trials have been performed to evaluate the use of prophylactic PLT transfusions in non-bleeding, thrombocytopenic hematology-oncology patients. However no high-quality data exist to guide PLT transfusions in actively bleeding patients inclduing pediatric and adult medical and surgical patients. After hematology-oncology patients, cardiac surgery patients are the next largest group of PLT ...more »

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Goal 1: Promote Human Health

Submitted by (@garobert)

Hierarchical control of cardiac excitability

Imbalances in membrane excitability underlie a broad range of cardiac arrhythmias and conduction defects. Although we now know the genes encoding almost all ion channels, we have little understanding of how the macromolecular composition and relative numbers of different channel types is achieved to exert exquisite control over membrane potential changes in time. Even minor changes in this balance can lead to sudden ...more »

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator)

Understanding Cardiothoracic Surgery in Elderly Populations

There is a vital need for evidence-based clinical evaluation tools to assess operative risk and post-operative recovery in the elderly, including biomarkers of physiologic age and a simple/reliable clinical evaluation scheme to determine frailty as a risk factor for poor surgical outcomes.

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Cardiovascular dysfunction in geriatric trauma patients

There is too little research funding addressing cardiovascular dysfunction in geriatric trauma patients. There have been little interest in funding this work. Yet, the geriatric population is growing. Geriatric trauma patients are predominantly women. Historically, the trauma societies provide guidance for diagnosis and treatment of severe trauma. However, "trauma guidance" historically was the same for children, ...more »

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Goal 2: Reduce Human Disease

Submitted by (@dayam0)

Benefits of intraosseous access on outcomes from OHCA

Vascular access is a challenge in the setting of out-of-hospital cardiac arrest (OHCA). The failure of medications to impact outcomes may be in part related to the delay in drug delivery from the IV route. EMS systems have adopted intraosseous (IO) access but it is not clear if these are affecting outcome and there has been no large RCT. The current IO access devices are expensive and use different routes (sternal, tibia, ...more »

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Goal 4: Develop Workforce and Resources

Submitted by (@jeromekalifa)

Promotion of interdisciplinary science to address therapeutic challenges in cardiac arrhythmias management

The main therapeutic challenges that remain to be addressed in the field of cardiac arrhythmias generally require the participation of scientific expertises as diverse as physiology, medicine, engineering, chemistry, nanotechnology, material science and others. Today, there is little incentive to assemble such cross-expertise teams. Novel funding mechanisms could reward the time and effort invested in forming cross-expertise ...more »

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