Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Impact of intrauterine environment on obesity

How does maternal obesity before or during pregnancy affect the intrauterine environment and increase the risk of overweight/obesity in the offspring?

How does maternal dietary intake during pregnancy impact weight in the offspring?

What types of interventions are most effective for preventing excessive gestational weight gain among high risk groups?

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Goal 2: Reduce Human Disease

Submitted by (@jsullivan)

Prevent the Development of COPD

What can be done to prevent the development of COPD in individuals at increased risk. Quitting smoking before the development of COPD can prevent COPD development. What can be done to prevent COPD for individuals with other identified ris factors

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15 net votes
18 up votes
3 down votes
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Goal 2: Reduce Human Disease

Submitted by (@jennifergrobinson)

How can we implement what we already know for ASCVD prevention?

We have a number of highly effective evidence-based interventions that have been shown to reduce ASCVD events - statins, BP drugs, aspirin, acute care. Yet large proportions of high risk population groups are not taking evidence-based treatment. Numerous interventions have been tried at multiple levels from the individual patient to the federal government payors. What are the best practices? How can we systematically ...more »

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-9 net votes
3 up votes
12 down votes
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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

What is the role of the environment in HLB disease etiology

It is clear that genetic sequence variation does not account for a substantial portion of disease burden. It is likely that the broad environment contributes to HLB disease via epigenomic alterations and interaction with genetic variants. There is an urgent need to understand the environmental contribution to disease as most exposures are modifiable and are targets for prevention interventions.

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4 net votes
11 up votes
7 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@skumanyi)

Research training to support population-focused obesity research in ethnic minority populations

NIH is already facing a challenge in increasing the number and viability of researchers of color. Obesity research in black (or other high risk minority) populations can be used to explore how research training programs that focus on specific issues of importance to populations of color might contribute to the recruitment and success of ethnic minority researchers in the NIH system.

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6 net votes
6 up votes
0 down votes
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Goal 2: Reduce Human Disease

Submitted by (@jennifergrobinson)

Cardiovascular risk and adverse event prediction & estimating net benefit in statin-treated individuals

Compelling Question: There is insufficient data to personalize the use of nonstatin or other preventive therapies in statin-treated patients. Equations could then be developed to predict CVD risk and to predict the risk of adverse events in statin-treated patients to guide intensification of therapy.

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3 net votes
11 up votes
8 down votes
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Goal 2: Reduce Human Disease

Submitted by (@kerstilinask)

Environmental induction of congenital heart defects and finding means of prevention

Congenital heart defects (CHDs) continue to be the leading cause of death among all infants with birth defects. It is reported that approximately 10% of cardiac congenital anomalies have a genetic basis. An equal percentage, or ~10%, is due to environmental factors. For ~60% the etiology is unknown and considered to have a multifactorial basis, eg, environmental agents having a role against a specific genetic background, ...more »

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-7 net votes
16 up votes
23 down votes
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Goal 1: Promote Human Health

Submitted by (@klk370)

Basic understanding on the mechanisms of overeating

We have an in depth understanding of the effects nutrients and diet have on the development of chronic disease, yet very little research funding has gone to understanding the basic mechanisms of eating behavior and how to successful change diet. There are currently no study sections at NIH that specialize in nutrition and/or human eating behavior, and therefore proposals in this subject area get farmed out to other study ...more »

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-3 net votes
17 up votes
20 down votes
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