What does early COPD actually look like. This is defined as severe COPD 30 years prior to its manifestation.
How can the structure and function lost in COPD be restored?
COPD hospitalizations a. Define the pathobiological changes that lead to severe exacerbations that cause hospitalizations b. Define novel clinical and biological phenotypic characterizations of hospitalized patients who fail treatment that results in death or early readmission c. Explore new or understudied therapies for treatment of acute COPD hospitalizations: antioxidant, non-steroidal anti-inflammatory (STATIN or... more »
Define the pathobiology of the disorder (COPD)
a. Mechanisms of lung injury
b. Mechanisms of lung repair
c. Balance of lung and systemic pathobiologic manifestations and mechanisms
a. Better tools for early recognition
b. More research in self-management and communications technology to assist patients
What is the standard of care for stable COPD and acute exacerbation of COPD that should constitute the reference base for clinical trials?
Medical marijuana and COPD
There needs to be a rehab type maintenance study for COPD patients to determine if such a program would slow progression, improve health and reduce exacerbations/hospitalizations going forward. Thus, reducing costs to patient/hospital/public aid programs.
1) Refinement of COPD subphenotypes for therapeutics, diagnostics and mechanistic interrogation. The NIH should encourage a strong focus on a) rigorous, mechanistically-reinforced definitions (chronic bronchitis, emphysema (with and without obstruction), frequent exacerbators, combined pulmonary fibrosis and emphysema) and 2) the development and optimization of animal model systems that replicate the different subphenotypes.... more »
Society is ageing and chronic degenerative diseases including COPD are increasingly occurring together. The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions 1. Which diseases are occurring concurrent with COPD more than chance alone would... more »
COPD is a major health problem leading to 140,000 deaths in the United States. Treatments are supportive, but there is a compelling need for treatments that modify the progression of the disease and that prevent exacerbations. There needs to be a research infrastructure that unites basic, translational, and clinical researchers to develop new approaches. Although this challenge had been met in the past with the now... more »
The GOLD guidelines recommend regular physical activity in all patients with stable COPD. How we operationalize this is completely unclear. We know pulmonary rehab works but few patients are referred and fewer participate. We also know physical activity, not just exercise, directly measured in the field is associated with COPD-specific outcomes such as acute exacerbations, hospitalizations and death. How do we bring... more »
What is the effectiveness of the telemonitoring system to detect and trigger treatment for COPD exacerbations?
What are the comparative benefits of oral corticosteroids and antibiotics versus oral corticosteroids alone for outpatient COPD exacerbation?
Specific biomarkers to monitor COPD disease activity are needed.