Goal 2: Reduce Human Disease

Physical Activity and Sedentary Behavior Research

There is a need to enhance research efficiency for physical activity and sedentary behavior research by facilitating standardization of the definition of sedentary behavior; employing research strategies that support reliable, valid, and efficient ways to measure and analyze sedentary behaviors; supporting better approaches for data harmonization to promote comparability across studies; and facilitating the use of platforms ...more »

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

It will enhance the feasibility of conducting activity-related trials and facilitate data harmonization to better inform interpretation of research findings

Feasibility and challenges of addressing this CQ or CC :

The US population is mostly sedentary and the health effects of inactivity is very costly. Doing nothing in this area will likely lead to more population-level and individual-level adverse health outcomes that would be costly fiscally.

A large amount of epidemiological data indicate potentially serious health risks of sedentary behaviors and physical inactivity. Identifying and testing effective and translatable sedentary behavior interventions would have a measurably beneficial impact on population health. They could also be potentially cost-effective compared to other types of intervention.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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75 up votes
31 down votes
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Goal 2: Reduce Human Disease

Can transcutaneous carboxyhemoglobin measure endogenous heme oxygenase activity?

Non-invasive measurement of transcutaneous carboxyhemoglobin (SpCO) by CO-oximetry has been shown to reflect disease activity in asthma, allergic rhinitis, Staphylococcal pneumonia/sepsis and to correlate positively with lung function in cystic fibrosis. Given published studies of heme oxygenase activity in these diseases as a reflection of oxidant or inflammatory activity, does measurement of SpCO reflect endogenous ...more »

Submitted by (@lekurlandsky)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Laboratory measurement of heme oxygenase activity in inflammatory and states of oxidative activity in multiple disease states, lung diseases for instance, has become important in measuring disease severity and activity as well as being an indicator of disease modification by gene polymorphisms of heme oxygenase. The simple measurement of transcutaneous carboxyhemoglobin if correlated with heme oxygenase activity would provide a ready assessment for clinicians in the clinical setting.

Feasibility and challenges of addressing this CQ or CC :

In a setting in which heme oxygenase activity is measured and clinical patients of varying diseases are available, this question could be answered reasonably easily without technical difficulty.

Name of idea submitter and other team members who worked on this idea : Lawrence E. Kurlandsky, MD

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-24 net votes
1 up votes
25 down votes
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Goal 1: Promote Human Health

Prevention of Obesity

What are the behavioral factors that predispose to excessive weight gain and development of obesity? And, which intervention strategies can effectively prevent excessive weight gain and obesity? NHLBI, other NIH institutes and the society at-large have invested heavily in research and clinical practice aimed at treatment of obesity (i.e, weight loss in those who are already overweight). However, much less research ...more »

Submitted by (@rpate0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Reducing the prevalence of obesity is one of the great public health challenges of the 21st century. Research should be focused, first and foremost, on prevention, not treatment, of this problem. It seems highly likely that improving the behaviors that can prevent obesity would produce a wide range of important public health benefits.

Feasibility and challenges of addressing this CQ or CC :

Two generations ago the prevalence of obesity was much lower than it is today. The prevalence was lower then, not because overweight people were better at losing weight; rather rates were lower because far fewer people became overweight in the first place. It is high time that the scientific community, clinicians, and public health practitioners invested their efforts in prevention first, where there is every reason to believe we could be successful. These efforts should be informed by a robust body of knowledge, and it is recommended that NHLBI lead the effort to expand the body of knowledge on primary prevention of obesity.

Name of idea submitter and other team members who worked on this idea : Russell Pate

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6 net votes
8 up votes
2 down votes
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Goal 2: Reduce Human Disease

Promoting Physical Activity in COPD

The GOLD guidelines recommend regular physical activity in all patients with stable COPD. How we operationalize this is completely unclear. We know pulmonary rehab works but few patients are referred and fewer participate. We also know physical activity, not just exercise, directly measured in the field is associated with COPD-specific outcomes such as acute exacerbations, hospitalizations and death. How do we bring ...more »

Submitted by (@marilynmoy)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Marilyn Moy,MD

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4 net votes
5 up votes
1 down votes
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Goal 1: Promote Human Health

Establishment of a Human-Animal Interaction (HAI) research program at NHLBI

NICHD has a human-animal interaction (HAI) research program dedicated to advancing knowledge of the health benefits and therapeutic uses of animals for children, but no comparable program exists for NIH research with adults. As many of the potential health benefits/therapeutic uses of companion animals relate directly to cardiovascular health (e.g., increased physical activity, reduced stress, reduced loneliness), NHLBI ...more »

Submitted by (@katiebecofsky)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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-14 net votes
7 up votes
21 down votes
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