Sudden Death from cardiac arrest and gaps in knowledge of emergency cardiovascular care are the #1 killer of more than 400,000 Americans each year. This epidemic of death and disability is largely ignored and underfunded by NIH and all funding agencies and kills more than HIV, Cancer, Diabetes, and infectious diseases. There is no national registry of cardiac arrest, no mandatory reporting, and poor funding for both fundamental, ...more »
What is the best way to train the public to recognize sudden cardiac arrest, perform CPR and utilize an AED?
Epinephrine is the primary drug that is used in resuscitation but observational studies and a few small RCT suggest that it improves short term but not long term outcomes. Factors such as timing, dose, quality fo CPR and post-resuscitation care all confound the issue. Large RCTs conducted at multiple centers are desperately needed to address this question.
What resuscitation strategies targeted toward pulseless electrical activity (PEA)/asystole would be successful in preventing cardiac arrest (CA)? Furthermore, what are animal models of PEA/asystole, what is responsible of this major shift in the underlying rhythm of CA, and what is the phenotype?
What is the sequence and time course of molecular events that cause irreversible cardiovascular and neurologic dysfunction during and after cardiac arrest?
Can techniques to monitor brain injury and recovery in post-cardiac arrest patients be developed to optimize post-cardiac arrest care and enable reliable neuroprognostication?
Can surveillance systems be developed to prevent in-hospital cardiac arrest outside the ICU?
Is intra-arrest therapeutic hypothermia feasible during CPR, and does it improve outcomes?
How do we eliminate disparities in cardiac arrest care?
Should out-of-hospital cardiac arrest care be regionalized to specialized centers similar to trauma, STEMI, and stroke?
Which, if any, pharmacologic and non-pharmacologic therapies are useful and effective in cardiac arrest due to non-shockable rhythms?
Can personal surveillance systems to prevent “unwitnessed” cardiac arrest improve outcomes?