(@serevill)

Goal 2: Reduce Human Disease

Does lowering circulating lipoprotein(a) levels influence cardiovascular outcomes?

A comprehensive research strategy and plan is needed to determine the most efficient, safe, cost-effective and widely applicable strategy to decrease circulating levels of lipoprotein(a) and to determine whether lowering circulating lipoprotein(a) levels will reduce the risk of developing cardiovascular disease such as a heart attack or a stroke as well as the progression of atherosclerosis or aortic stenosis.

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235 net votes
297 up votes
62 down votes
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(@moshe.arditi)

Goal 2: Reduce Human Disease

More funding for Kawasaki Disease Vasculitis

Kawasaki Disease is the most common cause of acquired heart disease among children and we just started to understand that Kawasaki Disease 9 unrecognized during childhood) maybe responsible for a large number of adult atherosclerotic diseases and excellent animal models for this vasculitis exist and more funding should be allocated for this disease. We are now starting to understand that Kawasaki Disease is NOT a self ...more »

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2 net votes
2 up votes
0 down votes
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(@f.despa)

Goal 2: Reduce Human Disease

What pathobiology underlies the interaction of the diabetogenic hormone amylin with vascular media ?

Amylin is synthesized and co-secreted with insulin by pancreatic beta-cells, plays a complex role in peripheral energy homeostasis, and shows also a high propensity to oligomerize when overexpressed (hyperamylinemia). Accumulation of oligomerized amylin is a pathological hallmark of the islet in diabetic patients and induces oxidative stress, inflammation and apoptosis. However, recent studies found significant deposits ...more »

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3 up votes
9 down votes
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