(@dstrickland)

Goal 3: Advance Translational Research

Molecular determinants of vascular wall development and aneurysm formation that can be used as markers for early diagnosis

To increase the potential of translating basic research discoveries into the clinic, there is a need to discover molecular biomarkers that confer risk for aneurysms and vascular dissections. The creation of a nation-wide biorepository of well-defined tissue and plasma samples along with research utilizing these tissue samples employing state-of-the art proteomics, genomics and development of appropriate mouse models will... more »

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5 net votes
7 up votes
2 down votes
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(@docew0)

Goal 4: Develop Workforce and Resources

Creating research infrastructure through supporting the development of biorepositories and registries for rare lung diseases

Progress in rare lung diseases, such as interstitial lung diseases, has been hampered by a lack of patient-derived samples in large enough quantities or high-enough quality for systematic study. This is due to the inability of individual centers to recruit enough patients, and because of the varied samples each center obtains. Collecting, preparing, and storing such samples is not fundable by the NHLBI because it is not... more »

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-1 net votes
11 up votes
12 down votes
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(@chintamani.atreya)

Goal 2: Reduce Human Disease

Biorepository to facilitate epidemiologic studies of transfusion-transmitted diseases and validation of laboratory tests for don

There is a critical need for a proactive and coordinated effort to develop well-characterized biorepositories that can be used for epidemiologic studies of emerging infectious agents to expedite rapid implementation of donor screening tests for emerging pathogens and variants that pose a threat to the blood supply.

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3 net votes
12 up votes
9 down votes
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