Goal 2: Reduce Human Disease

Submitted by (@dayam0)

Reducing Variability in Outcomes from Out of Hospital Cardiac Arrest

Out of hospital cardiac arrest remains a major cause of mortality in the United States and there is a large variability in survival within communities. We need to better understand the reasons for this variability which include patient, event, EMS system and care processes and work as a nation to reduce the variability but adopting best practices and actively addressing the barriers to change which can be social, cultural, ...more »

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Pulseless Electrical Activity (PEA) - replacing VF/VT

As VF/VT rates continue to decrease in cardiac arrest to levels below 25%, the importance of understanding the pathways and epidemiology of PEA gains public health importance. Additionally, there is a need to determine the co-morbidities and/or pharmacologic agents that contribute to the causation of this rhythm.

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Goal 2: Reduce Human Disease

Submitted by (@dayam0)

Does epinephrine improve outcomes in OHCA

Epinephrine is the primary drug that is used in resuscitation but observational studies and a few small RCT suggest that it improves short term but not long term outcomes. Factors such as timing, dose, quality fo CPR and post-resuscitation care all confound the issue. Large RCTs conducted at multiple centers are desperately needed to address this question.

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Goal 4: Develop Workforce and Resources

Submitted by (@jeromekalifa)

Promotion of interdisciplinary science to address therapeutic challenges in cardiac arrhythmias management

The main therapeutic challenges that remain to be addressed in the field of cardiac arrhythmias generally require the participation of scientific expertises as diverse as physiology, medicine, engineering, chemistry, nanotechnology, material science and others. Today, there is little incentive to assemble such cross-expertise teams. Novel funding mechanisms could reward the time and effort invested in forming cross-expertise ...more »

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