Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator)

Heart transplant surveillance

It is essential to develop clinically viable, non-invasive, less expensive technologies for the surveillance of allograft rejection in heart transplant patients. Critical challenges that exist in the near term or long term surveillance after transplant is the unavailability of molecular and cellular level markers that can be non-invasively imaged and quantified detect rejection and thus improve patient survival. Development ...more »

Voting

1 net vote
14 up votes
13 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@maierl)

Define the biological basis, new diagnostics and therapeutics for severe sarcoidosis phenotypes

Sarcoidosis affects individuals of all races and ages and both genders, although it tends to cause significant morbidity and mortality for people in the prime of their productive life. Women, minorities and underserved populations tend to be more affected. Recent studies suggest that sarcoidosis and its severe manifestations, such as cardiac, neurologic and end stage pulmonary disease' are increasing, While the current ...more »

Voting

1 net vote
3 up votes
2 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator)

Detection of rupture prone small aortic aneurysms

Critical challenges in the assessment of aortic aneurysms are: (1) Availability of reliable animal models that simulate the human pathology, (2) Availability of molecular imaging resources – identification of biomarkers, development of targeted imaging probes and pre-clinical imaging methods, and plasma markers that predict whether an aneurysm is prone to rupture or dissection, (3) Bringing together a wide array of multi-disciplinary ...more »

Voting

7 net votes
18 up votes
11 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@danacpeters)

5-minute MRI exam

MRI is a lengthy and expensive exam, but this is mainly because it has no ionizing radiation and is uniquely safe and uniquely versatile, leading to imaging sessions that last for 1/2 to 1 and 1/2 hours, with multiple scans, views and contrasts. MRI could provide better quality screening scans, compared to x-ray, ct or echo, in 5 minutes, without ecg-gating and lengthy preparation of the patient. However, the optimal ...more »

Voting

0 net votes
1 up votes
1 down votes
Active