(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Detection of rupture prone small aortic aneurysms

Critical challenges in the assessment of aortic aneurysms are: (1) Availability of reliable animal models that simulate the human pathology, (2) Availability of molecular imaging resources – identification of biomarkers, development of targeted imaging probes and pre-clinical imaging methods, and plasma markers that predict whether an aneurysm is prone to rupture or dissection, (3) Bringing together a wide array of multi-disciplinary... more »

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(@haslach)

Goal 2: Reduce Human Disease

Mechanics of aortic dissection

The mechanical events in the wall leading to aortic dissection are not well described because merely stating that cellular or biopolymer connections have weakened does not predict the path of the rupture through the media or the risk of rupture. Elucidate the mechanical role of substructures such as collagen fibers, elastin sheets, smooth muscle cells and interstitial fluid in the progression of dissection. Study in animal... more »

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(@jgrima)

Goal 3: Advance Translational Research

How can we determine a patient’s risk of a life-threatening aortic dissection?

Even though science and technology has advanced, many of the advancements have not met the critical challenge of making significant changes in patient therapies for improved outcomes and thus have not been able to break through the translational barrier. In today’s world, risk of aortic dissection is still based purely on a crude size measurement. It is true that evidence indicates that aortic root aneurysm above 4.5... more »

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