What is the dynamic range of homeostasis (limits of resilience) for lung biology? What makes a lung resilient across the life span and to environmental insults?
What is the secret behind the “resilience” some people have to heart, lung, blood, and sleep (HLBS) diseases?
What are the molecular and cellular responses in the lung that occur after environmental stimuli that predict homeostatic resilience or transition to disease, disorder, or aging?
What is the measureable normal human variation at the -omic, cellular, organ, and system levels within the population and across the lifespan? • What are the range of normal human cellular functions that create resilience at all levels—cells, organs, organ systems? • What inter-organ, tissue, and cellular communications maintain individual health and the health of populations? • How do we understand why individuals with ...more »