(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Environmental stimuli and the lung: predictors of homeostatic or pathological responses

What are the molecular and cellular responses in the lung that occur after environmental stimuli that predict homeostatic resilience or transition to disease, disorder, or aging?

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10 net votes
15 up votes
5 down votes
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(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Lung Transplantation

As in other solid organ transplants, adherence to the medical regimen after adult and pediatric lung transplantation is less than ideal and contributes to poor health outcomes. a) How can we improve the prediction of which lung transplant recipients are at greatest risk for nonadherence? b) What are the most efficient and effective ways of assessing nonadherence in the clinical setting? c) Conduct clinical trials of... more »

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1 net vote
1 up votes
0 down votes
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(@john.alcorn)

Goal 2: Reduce Human Disease

Impact of Successive Acute Lung Injury on Subsequent Challenge

A great deal of focus has been placed on understanding chronic lung diseases such as asthma and CF. Long term changes in inflammatory and epithelial processes are well documented in this area. However, less research has addressed the impact of successive pulmonary injuries and how these seemingly acute events shape the lung response. This is the crux of the multi-hit theory regarding interstitial lung disease. Many acute... more »

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-10 net votes
4 up votes
14 down votes
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Goal 2: Reduce Human Disease

Optimization of Existing Therapies for Sickle Cell Disease

How can the safety, dosing and benefits of existing therapies for sickle cell disease such as hydroxyurea, be optimized in order to increase its efficacy and improve patient adherence?

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54 net votes
74 up votes
20 down votes
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(@mnicolls)

Goal 3: Advance Translational Research

Developing animal models of lung transplantation.

Lung transplantation as a cure for terminal lung disease has seen little improvement in outcomes for more than 20 years. The field remains highly challenging, in part, because of an absence of robust animal models which are technically- feasible and reproducible across centers. Further, models have limited relevance to clinical (chronic) airway remodeling, the leading problem in pulmonary allografts. In the absence of... more »

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5 net votes
15 up votes
10 down votes
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(@dcenter)

Goal 2: Reduce Human Disease

Improve Repair of injured lung

Why can’t we improve outcomes following acute lung injury. A half century of ICU interventions have resulted in only incremental improvements in survival and morbidity following acute lung injury. While we have pursued innumerable strategies for decreasing ventilator associated exacerbation of lung injury, we have failed to identify treatable common or selective pathways from the initial injury that can be targeted post... more »

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5 net votes
8 up votes
3 down votes
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