What are the biological, environmental, social and economic determinants of health in rural areas related to COPD and other lung disease.
Does pulmonary rehabilitation or regular exercise improve outcomes in patients with PVD?
As in other solid organ transplants, adherence to the medical regimen after adult and pediatric lung transplantation is less than ideal and contributes to poor health outcomes. a) How can we improve the prediction of which lung transplant recipients are at greatest risk for nonadherence? b) What are the most efficient and effective ways of assessing nonadherence in the clinical setting? c) Conduct clinical trials of... more »
Using knowledge of matrix biology and lung development, what are useable methods to modify cadaveric donor lungs to provide a durable, effective organ replacement therapy?
Does treatment with spironolactone improve outcomes in patients with pulmonary arterial hypertension (and/or pulmonary hypertension associated with diffuse parenchymal lung disease or COPD)? Spironolactone has been shown beneficial in CHF and many of the same mechanisms are at plan in RV failure from pulmonary hypertension. Again, no clear evidence whether this is a useful treatment or not, and no evidence to guide... more »
How does insufficient sleep duration, irregular timed sleep schedules, and poor sleep quality contribute to the pathophysiology of lung, heart and blood diseases?
Is FVC a valid surrogate for mortality in patients with idiopathic pulmonary disease?
Can a multipronged approach to reversing/repairing scar tissue in pulmonary fibrosis be deployed as soon as possible?
What is the relationship of ChILD disorders to other clinical populations that manifest ILD?
How does insufficient sleep impair hormonal, cellular, and tissues barriers mediating lung immunity and risk of lung infection?
More emphasis must be placed on systemic manifestations and co‐morbidities of chronic lung disease such as depression, oral disease and heart disease.
What is the relationship of ChILD disorders to adult diffuse lung disease?
As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:
What are the molecular and cellular responses in the lung that occur after environmental stimuli (including allergens) that predict homeostatic resilience or transition to atopic diseases?
What are the regional variations in cellular and molecular characteristics (from epigenetics to microbiome) in the lung, and what controls these variations?