Translation means laying the groundwork to advance an idea into the clinic. Late-stage translation means doing what FDA and IRBs require to obtain approval for an IND or an IDE and the associated protocol to test a new idea in humans. Mechanism is the mantra for investigator-initiated research in NIH study sections, but translation is often painstaking detailed work that follows mechanistic investigations, which typically... more »
What molecular and cellular pathways explain the sex-specific differences in the prevalence, severity, and progression of lung diseases?
There are compelling data regarding the sex-dependent intersection of depression and cardiovascular disease (both IHD and stroke). There are early data suggesting the underlying mechanisms. CVD is the number one cause of death in women and depression is the number one cause of disability with women 70% more likely to experience depression over their lives. The underlying sex-dependent mechanism is important to elucidate.... more »
What is the molecular mechanism by which new drug therapies propose to reduce the severity and duration of hospitalization and opioid pain medicines? And how does that impact the course of disease progression?