Goal 1: Promote Human Health

Submitted by (@heartjpc)

New technologies for Personalized health monitoring: too much or not enough

The development of personalized medicine and the increasing amount of information extracted from individual and patients throughout their life is expected to growth significantly. Multiple types of physiological sensors are currently embedded in everyday-life objects and yet their clinical value and their potential to improve health care is not well defined. It seems fundamental that the NIH develops a core research group/ ...more »

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8 down votes
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Goal 2: Reduce Human Disease

Submitted by (@greg.martin)

Consequences of drug interactions leading to QTc prolongation

Better understand the consequences of drug interactions leading to QTc prolongation. About 1/3 of cardiac ICU patients develop QT prolongation and about 45% receive drugs that are possibly contributing to this problem. The full spectrum of contributors and causes, as well as the patient-centered and health-system-centered clinical outcomes, are not known.

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-1 net votes
1 up votes
2 down votes
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Goal 2: Reduce Human Disease

Submitted by (@brent.palmer)

Influence of the Gut Microbiome on Pulmonary Immunity in HIV-Infected Individuals

It has become increasingly clear that gut microbiota have a tremendous impact on human health and disease. While it is well known that commensal gut bacteria are crucial in maintaining immune homeostasis in the intestine, there is also evidence of indirect effects on the lung. Multiple studies have shown that alterations in gut microbiota can lead to severe defects in pulmonary immune responses and reduced ability to ...more »

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3 net votes
7 up votes
4 down votes
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Goal 3: Advance Translational Research

Submitted by (@greg.martin)

Durable gene activity map at the individual level

A durable gene activity map of the individual to understand when certain gene sets are on vs off or dysfunctional over an individual’s lifetime as one way of guiding the precision of medicine for that patient. It would need to be person portable and universally exportable and interpretable across all of the EHRs.

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3 up votes
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Goal 3: Advance Translational Research

Submitted by (@zbigniew.m.szczepiorkowski)

TREATMENT OF SEPSIS-MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS) UTILIZING APHERESIS BASED STRATEGIES

Sepsis, a systemic inflammatory response to infection, is the most common cause of death in non-cardiac intensive care units. The incidence and severity of sepsis have increased over the last two decades. With advances in supportive care, sepsis carries a mortality that averages 17%, however, this figure increases to 50 - 80% in Multiple Organ Dysfunction Syndrome (MODS), defined as failure of 3 or more organ systems. ...more »

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97 net votes
115 up votes
18 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Harnessing the ongoing ‘natural experiments’ of quality improvement

How do we harness the ongoing “natural experiments” of quality improvement (QI) activities in various healthcare systems to facilitate hypothesis-driven research, improve scientific validity to address questions in clinical trials, and implement and disseminate research results? • Current restrictions in human subjects research regulations • Diversity in approaches and methodology rigor to QI initiatives across different ...more »

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-2 net votes
11 up votes
13 down votes
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Goal 3: Advance Translational Research

Submitted by (@jalees)

Regenerative Medicine 2.0 in Heart and Lung Research - Back to the Drawing Board

Stem cell therapies have been quite successful in hematologic disease but the outcomes of clinical studies using stem cells for cardiopulmonary disease have been rather modest. Explanations for this discrepancy such as the fact that our blood has a high rate of physiologic, endogenous turnover and regeneration whereas these processes occur at far lower rates in the heart and lung. Furthermore, hematopoietic stem cells ...more »

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7 net votes
11 up votes
4 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@zbigniew.m.szczepiorkowski)

DEVELOPMENT AND SUPPORT FOR APHERESIS MEDICINE INVESTIGATORS

The apheresis medicine encompasses treatment of numerous diseases many of which are directly related to blood, lung and heart. However, there are very limited opportunities for training young investigators in basic and translational research related to Apheresis Medicine. There is a need to promote Apheresis Medicine as a viable field of research for junior and established investigators. The influx of well-trained junior ...more »

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108 net votes
127 up votes
19 down votes
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Goal 3: Advance Translational Research

Submitted by (@bconklin)

Use isogenic iPS cells to advance Precision Medicine

The goals of Precision Medicine can be achieved if we determine the biological basis of disease-associated variants for NHLBI diseases. Advances in genetic research have yielded hundreds of disease-associated DNA polymorphisms, yet we lack robust methods to experimentally test their functional relevance in human cells. Determining the molecular and cellular basis of human phenotypic variation is one of the great challenges ...more »

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-19 net votes
8 up votes
27 down votes
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Goal 2: Reduce Human Disease

Submitted by (@murry0)

Stem Cell Immunology

We now can create critical cell types like cardiomyocytes etc. from stem cells. Additionally, we are learning the rules of using these cells to rebuild tissues. A major gap in our knowledge relates to the immunobiology of these cells. Lessons from transplantation medicine are only partially applicable, because solid organs are more complex and likely more immunogenic than defined cell populations. How does the immune ...more »

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23 net votes
45 up votes
22 down votes
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