Goal 2: Reduce Human Disease

Can transcutaneous carboxyhemoglobin measure endogenous heme oxygenase activity?

Non-invasive measurement of transcutaneous carboxyhemoglobin (SpCO) by CO-oximetry has been shown to reflect disease activity in asthma, allergic rhinitis, Staphylococcal pneumonia/sepsis and to correlate positively with lung function in cystic fibrosis. Given published studies of heme oxygenase activity in these diseases as a reflection of oxidant or inflammatory activity, does measurement of SpCO reflect endogenous ...more »

Submitted by (@lekurlandsky)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Laboratory measurement of heme oxygenase activity in inflammatory and states of oxidative activity in multiple disease states, lung diseases for instance, has become important in measuring disease severity and activity as well as being an indicator of disease modification by gene polymorphisms of heme oxygenase. The simple measurement of transcutaneous carboxyhemoglobin if correlated with heme oxygenase activity would provide a ready assessment for clinicians in the clinical setting.

Feasibility and challenges of addressing this CQ or CC :

In a setting in which heme oxygenase activity is measured and clinical patients of varying diseases are available, this question could be answered reasonably easily without technical difficulty.

Name of idea submitter and other team members who worked on this idea : Lawrence E. Kurlandsky, MD

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Goal 2: Reduce Human Disease

Gasotransmitter regulation of cardiovascular and lung health and disease

Gasotransmitters, such as nitric oxide, hydrogen sulfide, carbon monoxide, and hydrogen, have emerged as potent mediators of cardiovascular and lung cellular and molecular pathophysiology. While the physiological importance of these agents is becoming clearer, studies of gasotransmitters continue to suffer from several limitations such as formation, detection, metabolism, and molecular and cellular mechanistic insights. ...more »

Submitted by (@ckevil)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

It is well known that gasotransmitters participate in numerous aspects of cardiopulmonary physiology and pathology. However, several limitations exist with regard to how and when changes in gasotransmitters may occur during disease versus health, and whether employing gasotransmitters in a therapeutic manner could alleviate pathology and/or maintain physiological homeostasis. Support of research addressing mechanisms of gasotransmitter formation and metabolism, clinical and experimental pathophysiological detection, and clinical and experimental therapeutic approaches will significantly advance the field along with understanding of multiple cardiopulmonary disease processes.

Feasibility and challenges of addressing this CQ or CC :

Given the significant advances in quantitative analytical chemical and molecular techniques, molecular mediators and pathways, non-invasive imagine modalities and comprehensive translational study designs; multiple fields are uniquely poised that could provide significant insight into this critical challenge. Primary objectives would be to establish consensus analytical methodologies, (bio)chemical and molecular biology approaches, and cellular and animal models along with rigorous clinical investigations. Results from efforts at understanding the importance of gasotransmitters will make significant clinical impact on cardiovascular and pulmonary diseases that would feasibly be accomplished in 5-10 years.

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