Sepsis, a systemic inflammatory response to infection, is the most common cause of death in non-cardiac intensive care units. The incidence and severity of sepsis have increased over the last two decades. With advances in supportive care, sepsis carries a mortality that averages 17%, however, this figure increases to 50 - 80% in Multiple Organ Dysfunction Syndrome (MODS), defined as failure of 3 or more organ systems. ...more »
A genetically engineered and humanized pig organ expressing human genes and devoid of antigens immunogenic to humans may prove to be an ideal solution to overcome the acute organ shortage for solid organ transplantation. Recently, a remarkable progress has been made in this direction with reports of graft survival approaching 3 yrs in a pig to primate cardiac transplantation model.The issues of viral transmission and ...more »
Does hydroxyurea preserve organ function in patients with sickle cell disease?