(@societyforvascularsurgery)

Goal 3: Advance Translational Research

Cohort studies and clinical trials in vascular disease

Utilization of well characterized cohort studies and clinical trials to conduct ancillary scientific studies on pathophysiology, responses to treatment, and identify new ways to predict and treat disease. Restore the Ancillary Studies mechanism. Improved biobanks and data sharing platforms are needed. Facilitate public-private partnerships.

Voting

2 net votes
3 up votes
1 down votes
Active
(@nhlbiforumadministrator1)

Goal 2: Reduce Human Disease

Enabling technologies that improve the precision and depth by which we evaluate people

How do we enable technologies that improve the precision and depth by which we evaluate patients to better understand pathophysiology and develop, test and optimize therapy?

 

Use of EHR to understand HLB disease?

Should NHLBI/researchers have a larger role in the development of the EHR?

Voting

5 net votes
16 up votes
11 down votes
Active
(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Characterizing tissue response to injury

Can we characterize in detail the nature of tissue response to injury, resulting in either aberrant repair or regeneration, to generate predictive algorithms and targetable nodes where manipulation can alter the outcome?

 

Can we characterize tissue remodeling, repair and injury? What processes are involved that lead to outcome X and dependent on various perturbegens, genetics? How do you translate that?

Voting

13 net votes
22 up votes
9 down votes
Active
(@john.buolamwini)

Goal 3: Advance Translational Research

Developing Curative Approaches to Cardiovascular Disease rather than Chronic Magement

Most Pharmacological interventions in cardiovascular diseases tend to address to be used in palliative manner and chronically. There is urgent need for treatments that are curative. This goes to identifying molecular drivers of the diseases and targeting them to correct the underlying pathophysiology rather than symptom suppression.

Voting

1 net vote
2 up votes
1 down votes
Active
(@rlevine)

Goal 3: Advance Translational Research

The need for funding priorities and emphasis on valve disease and large-animal preclinical studies

Investigators need NHLBI support for programs that transform our approach to heart valve disease to mechanism-based prevention with large-animal preclinical studies through: an NHLBI-sponsored sponsored Heart Valve Network; development of models of genetic and acquired valve disease; a study section devoted to valve disease; and RFAs and RFPs based on Task Force priorities in mitral valve disease.

Voting

2 net votes
4 up votes
2 down votes
Active