In the US, what kind of diet(s) is/are best for preventing hard cardiovascular events?
Pragmatic and adequately powered clinical trials are an ongoing challenge.
Develop new tools to facilitate identification and recruitment of subjects, remote/wireless data collection, and functional measures.
Practiced-Based Research Networks (PBRNs) are critical for the conduct of pragmatic real world studies. Most PBRNs struggle to support their infrastructure. Funding is needed to support core administration and IT, i.e. electronic interfaces and data extraction, transfer and loading from multiple EHRs and PBRN registries. Continuous if not core funding is needed whether though Center (P) awards, through through NHLBI... more »
Does bariatric surgery reduce the risk of MI, stroke, heart failure, and premature death in moderately obese adults?
Does the type of surgery matter?
In adults without diastolic hypertension (DBP ≥ 90 mm Hg), what is the best way to determine at what systolic blood pressure should treatment be initiated?
Jumpstarting progress in eliminating health care disparities requires comparative effectiveness and implementation research (T3 and T4) regarding optimal strategies for ensuring health care equity in the real world. Ensuring minority and other socially disadvantaged groups receive and benefit from evidence-based interventions at the same rate as others requires pragmatic research that identifies and addresses barriers... more »
There is a need for the NHLBI to systematically assess CV guidelines that have public health importance and that can be addressed by pragmatic, government-funded trials.