What therapeutic strategies can reduce tissue and organ injury caused by total body ischemia and reperfusion?
Often under recognized, the cardiac endothelial cells are highly abundant in the heart, and may have important roles in modulating cardiac function, besides simply serving as structural component of blood vessels. Evidences of ours and others have indicated an emerging role of cardiac endothelial cells signaling to cardiomyocytes to mediate important pathophysiological responses. Nonetheless, detailed mechanisms of ...more »
What is the impact of age, gender, and comorbidities on pathophysiology and treatment of total body ischemia and reperfusion, and how should therapies be modified accordingly?
Sudden Death from cardiac arrest and gaps in knowledge of emergency cardiovascular care are the #1 killer of more than 400,000 Americans each year. This epidemic of death and disability is largely ignored and underfunded by NIH and all funding agencies and kills more than HIV, Cancer, Diabetes, and infectious diseases. There is no national registry of cardiac arrest, no mandatory reporting, and poor funding for both fundamental, ...more »
What is the mechanistic interaction of injured organ systems during total body ischemia and reperfusion?
What is the impact of total body ischemia and reperfusion on coagulation, inflammation, and endothelial function?