Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Basic Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related basic research can NHLBI support in the next 5-10 years to investigate the fundamental mechanisms of HIV-related heart, lung, and/or blood (HLB) diseases alone and in the context of antiretroviral therapy (ART) to improve heart, lung, and blood health outcomes in HIV infections as well as the fundamental mechanisms of hematopoietic stem cell transplantation in potential elimination or eradication ...more »

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-22 net votes
14 up votes
36 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Harnessing the ongoing ‘natural experiments’ of quality improvement

How do we harness the ongoing “natural experiments” of quality improvement (QI) activities in various healthcare systems to facilitate hypothesis-driven research, improve scientific validity to address questions in clinical trials, and implement and disseminate research results? • Current restrictions in human subjects research regulations • Diversity in approaches and methodology rigor to QI initiatives across different ...more »

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-2 net votes
11 up votes
13 down votes
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Goal 3: Advance Translational Research

Submitted by (@sanjivkaul)

When will NIH truly support translational research?

There is a huge gap between basic science discoveries (some of which have no clinical application) and clinic practice (even when the basic science is related). Rarely do physicians, physician scientists, and basic scientists get together to answer a question that has public health or patient health impact. Without such an effort, a lot of taxpayer money is wasted on 'science for the sake of science' as well as in applied ...more »

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39 net votes
71 up votes
32 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@parise)

R01 funding

Unless we fix and increase the R01 funding rate, which most basic scientists depend upon, we will continue to lose outstanding scientists of all ages and not have the next generation of scientists or the numbers of currently outstanding scientists to answer any of these compelling questions and critical challenges. Related to this, much has been written about the significant failure rate of clinical trials in part due ...more »

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420 net votes
435 up votes
15 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@yyzhao)

Establishment of an independent study section on Pulmonary Vascular Biology and Translational Research

The research on pulmonary vascular biology including smooth muscle cell biology and endothelial cell biology and related pulmonary vascular diseases such as pulmonary hypertension and related right heart failure, and endothelial dysfunction in lung vascular inflammation and acute lung injury, as well as pulmonary embolism and lung transplantation has been rapidly expanding. The field is attracting an ever increasing ...more »

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23 net votes
50 up votes
27 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Implementation of T4 Translation Research Platforms and Networks

How can cost-effective implementation of late stage translation (T4) research protocols be facilitated for heart, lung, blood, sleep diseases and health inequities?

Can research platforms and networks be created and utilized to facilitate execution of multi-level interventions and approaches for the end user in collaboration with key stake holders?

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4 net votes
13 up votes
9 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@wheeze)

Modernizing Research Training

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

Since the focus of research has changed over the past decade, training programs need to be encouraged to use newer models of research in their training and mentoring of potential research faculty.

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10 net votes
23 up votes
13 down votes
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