(@yyzhao)

Goal 4: Develop Workforce and Resources

Establishment of an independent study section on Pulmonary Vascular Biology and Translational Research

The research on pulmonary vascular biology including smooth muscle cell biology and endothelial cell biology and related pulmonary vascular diseases such as pulmonary hypertension and related right heart failure, and endothelial dysfunction in lung vascular inflammation and acute lung injury, as well as pulmonary embolism and lung transplantation has been rapidly expanding. The field is attracting an ever increasing... more »

Voting

23 net votes
50 up votes
27 down votes
Active
(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Improving patient-centered outcome assessments in HLBS studies

What types of newer patient-centered quality of life assessment tools can be employed in heart, lung, blood and sleep studies so that they can be validated and refined to improve our measurement of quality of life outcomes in populations of interest to NHLBI?

Voting

11 net votes
20 up votes
9 down votes
Active
(@hongw0)

Goal 2: Reduce Human Disease

Mechanism and target identification for cardiovascular disease using database mining and experimental strategies

The big database of -omics and noncoding RNAs provide a valuable search engine to establish the link of various disease conditions with pathways and molecules. During recent year, data mining of available biomedical data and information has merged for target discovery and mechanism identification. However, current database mining research remains limited and largely hypothetical. Comprehensive research using the combinatory... more »

Voting

19 net votes
26 up votes
7 down votes
Active
(@dbdb00)

Goal 3: Advance Translational Research

Develop common-sense standards for obesity research

Obesity research is riddled with methodological problems that are rarely challenged, leading to the perpetuation of misinformation and interventions that do harm. Given the two-thirds of the population who are classified as higher weight and thus subject to these interventions, it is past time to clean up the basic scientific flaws in this research area. For a quick summary of a couple of these issues, see Poodle Science:... more »

Voting

24 net votes
44 up votes
20 down votes
Active
(@judith.l.bettencourt)

Goal 3: Advance Translational Research

Translational research supporting stem cell therapy for cardiovascular disease

Translational research supporting stem cell therapy for cardiovascular disease, including: core laboratories for preclinical IND-enabling studies (e.g., PACT), and clinical trials networks for evaluating promising new treatments (e.g., CCTRN).

Voting

115 net votes
149 up votes
34 down votes
Active
(@wheeze)

Goal 2: Reduce Human Disease

Behavioral Science in Asthma Clinical Research

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

Will integration of behavior science in clinical research improve effectiveness of interventions for asthma associated with behavioral risk factors? 

Voting

-5 net votes
8 up votes
13 down votes
Active
(@paulbrookes)

Goal 1: Promote Human Health

Adult Cardiomyocytes in Culture

So much basic cardiovascular discovery relies on cell culture models. While cardiac cell lines exist (e.g. HL-1, H9c2), these often poorly model aspects of cardiomyocyte function in-situ (e.g. contractile function, metabolism). In contrast, primary cardiomyocytes isolated from adult animals (especially mice!) are not readily amenable to culture conditions. Even if cells can be kept alive, they are often refractory to... more »

Voting

-25 net votes
12 up votes
37 down votes
Active
(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

A Program of Research in the Prevention of Chronic Heart Failure

There is a need to improve identification and surveillance of persons at risk for heart failure and pathological ventricular remodeling prior to development of clinically overt heart failure.

Voting

14 net votes
28 up votes
14 down votes
Active
(@jalees)

Goal 4: Develop Workforce and Resources

Reproducibility Initiatives in Heart, Lung and Blood Research

Scientists feel tremendous pressure to publish numerous scientific papers in order to receive NIH funding and tenure at academic institutions. Cognitive biases of scientists and publication biases of journals that publish this barrage of papers will likely result in the publication of findings that are probably not reproducible (see "Why Most Published Research Findings Are False" by John P. A. Ioannidis in PLOS Medicine... more »

Voting

2 net votes
5 up votes
3 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Trans-kingdom regulation of HLBS systems

What is the interplay of the micro- and macroenvironment and their effect on gene and protein expression and overall effect on phenotypes in HLBS systems?

 

Need for unbiased approaches for information capture. Technologies for capturing real time, dynamic and contextual information

Voting

-6 net votes
3 up votes
9 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Functional and high throughput screening assays

There is a need to develop functional assays and high throughput screening to develop probes and potential drug therapies. A. Functional Assays. Researchers face a challenging gap between identifying many sequence variations of potential interest and recognizing which of these variations have a direct functional effect on the physiological system of interest, as opposed to merely being associated with the actual causal... more »

Voting

-1 net votes
9 up votes
10 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Incentivizing Earlier Investment in NHLBI-Funded Technologies

How might NHLBI assist its awardees to attract private sector funding or partnerships earlier in the product development process to help bridge the gap between academic discoveries and product commercialization?

Voting

15 net votes
23 up votes
8 down votes
Active
(@teresabarnes)

Goal 2: Reduce Human Disease

Pick Me, Pick Me! The Challenges of Being at the Mercy of a Few

One significant challenge if you're a patient or a patient advocate is "who is going to find a life-saving treatment or cure for my disease. Who is going to Pick me and my disease?". The answer is complex but lies within the research community's priorities and interests. Think for a moment like a patient. You are at the mercy of the research community at large, government agencies and companies willing to make your... more »

Voting

-3 net votes
1 up votes
4 down votes
Active