Goal 2: Reduce Human Disease

Mechanical interaction of the cerebral vascular system with the brain parenchyma during mild traumatic brain injury

Dangerous mechanical interaction of the cerebral vascular system with the brain parenchyma during mild traumatic brain injury from either a blast wave or from impact may result from a combination of shear and compression deformation waves that causes non-diffusive extracellular fluid motion. Measure the mechanical response, to a combination of shear and compressive deformation, of animal model specimens containing the ...more »

Submitted by (@haslach)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Such research would give insight into the immediate mechanical causes of cerebral artery dissection or of mild traumatic brain injury that occur prior to observed biochemical responses and would lay a foundation for counter-measures.

Feasibility and challenges of addressing this CQ or CC :

Develop a mathematical model for the mechanical interaction of the vascular system with the brain parenchyma and for flow in the glymphatic system during mild traumatic brain injury to predict forces generated in the extracellular fluid and in the walls of the cerebral arteries.

Name of idea submitter and other team members who worked on this idea : Henry W. Haslach, Jr.

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Goal 1: Promote Human Health

Hypothermia and hemostasis after severe trauma

There is a need to employ new molecular tools to delineate the difference between beneficial and uncontrolled shock-induced hypothermia, because data on hypothermia and hemostasis are incomplete or lacking, especially on the duration, depth and type of hypothermia.

 

availability of targeted resource grant funding

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

improvement of survival with life threatening traumatic injuries with new metabolically modulating strategies, including "simple hypothermia", improved understanding of the relationship between ischemia and reperfusion, the role of inflammatory and metabolic pathways, definition and identification of appropriate targets for therapy, the role for mechanical devices, and relationship between timely application of hypothermia and rewarming.

Feasibility and challenges of addressing this CQ or CC :

the tools and animal models are available to study hemostatic and metabolic modulation/hypothermia in traumatic injury

Trauma is the major cause of death in young individuals in the US, and globally, with uncontrolled hemorrhage representing the major cause of preventable deaths. Hypothermia, used in life threatening cardiovascular states, also holds enormous promise for application in traumatic injuries. Early deployment (pre-hospital) of novel protective metabolically modulating strategies to attenuate cellular injury from shock and reperfusion, such as hypothermia could be beneficial. However, the relationship between hypothermia in traumatic setting is complex, with data suggesting detrimental outcomes if it occurred spontaneously. In contrast, hypothermia induced in a controlled manner can protect tissues from ischemic injury.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Goal 1: Promote Human Health

Hand Held Device to treat PTSD and Traumatic Brain Injury

Undo Obesity, Now! Hand Held Electronic Device to Treat Obesity Undo PTSD/TBI Hand held vagus nerve stimulator for PTSD and traumatic brain injury PTSD may be similar to depression and epilepsy. Traumatic brain injury may relate to nerve injury and nerve inflammation Vagus nerve stimulation causes nerve function regeneration. Vagus nerve stimulation stops inflammation. Vagus nerve stimulation treats depression. Vagus ...more »

Submitted by (@chrislahr22)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

This could revolutionize the treatment of PTSD and traumatic brain injury. No drugs, no surgery.

Feasibility and challenges of addressing this CQ or CC :

App is in development.

Power source and electrical wave generator produced by Apple

Stimulator cord produced by Apple.

Ear Stimulator in production by General Motors Global Research and Development.

Name of idea submitter and other team members who worked on this idea : Chris Lahr, Nitin Gupta,Derek Lahr, Christian R. Gomez, Ingrid Espinoza, Ryan Marshall, Thomas Abell, Omer H. Yilmaz

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