Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

A Systems Approach to Obesity

There is a need to use an integrated systems approach to obesity prevention and treatment. Obesity is a complex phenotype influenced by factors from the molecular to the socio-economic level. To address the causes and prevention of obesity, we need to integrate information at the molecular level with behavioral, social and environmental data. This will require investigators in molecular biology, genetics, epidemiology, ...more »

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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator1)

Public-Private Partnerships to Improve Nutrition & Reduce Obesity

How can we best encourage and support collaborations between academic researchers and industry partners to test strategies for changing nutritional choices and eating behaviors to healthier patterns that can improve obesity rates? Subquestions include issues around adopting healthier food choices in a variety of environments, effects of diet alteration, the methods and effects of enhancing healthier food flavors, understanding ...more »

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Severe obesity prevention in pediatric and community settings

What novel lifestyle and behavioral modification therapies are needed to prevent or treat youth with severe obesity (>99th percentile for BMI) versus those who are overweight?

 

Can we harness ongoing registries such as POWER (Pediatric Obesity Weight Evaluation Registry) in pediatric primary care (PC) settings to implement novel trials that would link PC and community settings to prevent severe obesity in youth?

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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator1)

Lifestyle Interventions for Weight Control

What is the comparative effectiveness in comparison to usual care of scalable alternatives for delivery of evidence-based, comprehensive, lifestyle interventions for weight control that physicians can prescribe to patients either within the primary care setting or by referral within the community? What kinds of infrastructure changes are needed within the primary care setting to increase the effectiveness of these interventions? ...more »

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Goal 2: Reduce Human Disease

Submitted by (@ryandh)

Optimizing weight loss

For patients with obesity and medical comorbidities, what is the optimal approach utilizing multiple therapies (low calorie structured diet, intensive lifestyle, weight loss medications) in combination to optimize weight loss?

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Impact of intrauterine environment on obesity

How does maternal obesity before or during pregnancy affect the intrauterine environment and increase the risk of overweight/obesity in the offspring?

How does maternal dietary intake during pregnancy impact weight in the offspring?

What types of interventions are most effective for preventing excessive gestational weight gain among high risk groups?

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