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Develop large epidemiologic cohorts of subjects with various types of chronic lung diseases with long-term follow-up of elements of disease progression and of related co-morbidities. These cohorts should be the substrate for comprehensive studies of genetics, omics, and biomarkers, as well as for clinical trials.
Integration of multiple Omics data types (genetics, transcriptomics, metabolomics, proteomics, and epigenetics) to understand susceptibility, progression, and heterogeneity of chronic lung diseases.
How can chest CT or other imaging tools be optimally used to characterize expression and progression of chronic lung disease?
What are the biomarkers that identify expression and progression of specific subtypes of chronic lung disease?
What are the subtypes of chronic obstructive lung disease that share a common pathogenesis and can be a basis for precision medicine?
What is the pathogenesis and appropriate treatment for subjects with chronic respiratory symptoms or imaging abnormalities who do not have overt airflow obstruction (and thus are not currently categorized as having COPD)?
What are the early life elements that contribute to the development of chronic lung disease? Strategies need to be developed for treatment/prevention of these elements.