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What are the knowledge and technological gaps in production, evaluation and clinical translation of donor-independent platelets for transfusions? Specific questions include: a) How can stem or progenitor cells be expanded to maximize platelet production?; b) What are the hemostatically relevant design and function requirements and evaluation metrics for ideal/optimal “biologic” and “synthetic” platelets? c) What preclinical ...more »
Will the development of a clinical grade “concentrated FFP” not only provide comparable efficacy to standard FFP, but also reduce the incidence of complications, especially transfusion-associated circulatory overload?