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Well-conducted international epidemiological studies with huge contrast of disease outcome and risk factor exposure will provide clues to disease prevention that cannot be obtained by studies solely within the US.
Cardiovascular field has been seeking novel risk factors which are 1) independently associated with clinical outcomes beyond and over traditional risk factors, and 2) powerful in identifying high risk individuals who are classified as intermediate risk by traditional model, e.g., Framingham Risk Score. Currently coronary artery calcification (CAC) is considered to pass the test. Seeking for new biomarkers that meet these ...more »