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This is critical to avoid having experienced researchers fall off the edge, so to speak, due to gaps in funding. There is a need for continued career support beyond the currently truncated K24.
Challenge is to have revised grants reviewed by the same reviewers, rather than delayed by new sets of reviewers. Also, having points such as changing model species addressable through Program Staff rather than prolonged re-review.
Investigators need NHLBI support for programs that transform our approach to heart valve disease to mechanism-based prevention with large-animal preclinical studies through: an NHLBI-sponsored sponsored Heart Valve Network; development of models of genetic and acquired valve disease; a study section devoted to valve disease; and RFAs and RFPs based on Task Force priorities in mitral valve disease.