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What are the institutional factors, including structure and culture of care, that characterize systems performance? Which of these factors are potentially modifiable and/or scalable?
The lack of large-scale data sources that provide a) detailed clinical phenotyping; b) longitudinal assessment of independent variables (incident events, medications, testing); c) collection of a broad range of outcomes, including patient-reported outcomes including health status.
How do we eliminate disparities in cardiac arrest care?
Can surveillance systems be developed to prevent in-hospital cardiac arrest outside the ICU?
Should out-of-hospital cardiac arrest care be regionalized to specialized centers similar to trauma, STEMI, and stroke?
What is the best way to train the public to recognize sudden cardiac arrest, perform CPR and utilize an AED?
Can personal surveillance systems to prevent “unwitnessed” cardiac arrest improve outcomes?
In what patient populations does extracorporeal cardiopulmonary resuscitation improve outcomes?
Can real-time monitoring of physiologic parameters during CPR be developed for use during goal-directed titration of therapy? Does goal-directed CPR based on real-time physiologic monitoring improve outcomes?
What physiologic parameters (and related technologies) might be useful to monitor and assess the adequacy of perfusion during CPR and to potentially guide therapy during resuscitation?
What is the impact of age, gender, and comorbidities on pathophysiology and treatment of total body ischemia and reperfusion, and how should therapies be modified accordingly?
There are numerous obstacles to the timely completion of trials, and there is a crisis in US enrollment rates. Overcoming barriers to timely completion of clinical trials would have a profound impact on accelerating research translation to improving health. Clinical investigations are necessary to advance the prevention, diagnosis, treatment and cures of human disease. The rate of basic scientific discovery has overwhelmed ...more »