Thank you for participating!

Thank you to all who contributed to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. Ultimately, over 1,000 ideas were submitted, with more than 42,000 votes. This remarkable response exceeded expectations and provided a wealth of ideas to draw upon as NHLBI moves forward. Please visit the NHLBI Strategic Visioning page to find out more about the NHLBI Strategic Visioning process.


Welcome to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. The Institute is gathering ideas for the most compelling scientific priorities in the four NHLBI Strategic Goals to address over the next decade.

(@pajohnson)

Goal 2: Reduce Human Disease

The Mechanisms Underlying the Connection Between Depression and CVD in women

There are compelling data regarding the sex-dependent intersection of depression and cardiovascular disease (both IHD and stroke). There are early data suggesting the underlying mechanisms. CVD is the number one cause of death in women and depression is the number one cause of disability with women 70% more likely to experience depression over their lives. The underlying sex-dependent mechanism is important to elucidate.... more »

Voting

1 net vote
3 up votes
2 down votes
Active
(@klk370)

Goal 1: Promote Human Health

Basic understanding on the mechanisms of overeating

We have an in depth understanding of the effects nutrients and diet have on the development of chronic disease, yet very little research funding has gone to understanding the basic mechanisms of eating behavior and how to successful change diet. There are currently no study sections at NIH that specialize in nutrition and/or human eating behavior, and therefore proposals in this subject area get farmed out to other study... more »

Voting

-3 net votes
17 up votes
20 down votes
Active
(@marilynmoy)

Goal 2: Reduce Human Disease

Promoting Physical Activity in COPD

The GOLD guidelines recommend regular physical activity in all patients with stable COPD. How we operationalize this is completely unclear. We know pulmonary rehab works but few patients are referred and fewer participate. We also know physical activity, not just exercise, directly measured in the field is associated with COPD-specific outcomes such as acute exacerbations, hospitalizations and death. How do we bring... more »

Voting

4 net votes
5 up votes
1 down votes
Active
(@gcioffi)

Goal 2: Reduce Human Disease

Combination Iron Chelator Trials in Thalassemia and other transfusion-dependent anemias

Three chelators are presently available in the US and much of the world: parenteral deferoxamine, and oral deferasirox, as well as oral deferiprone. Monotherapy is unsuccessful in a significant minority of patients, due to side effects or inadequate response at tolerable doses. Taking a page from enormously successful strategies for combination oral therapy in hypertension, led by NHLBI and others over the past four... more »

Voting

39 net votes
54 up votes
15 down votes
Active
(@treva0)

Goal 4: Develop Workforce and Resources

Expanding short term Junior Faculty Training Programs such as the Summer Training Programs for Junior Faculty (PRIDE): More Pgms

Expanding the training efforts (e.g. greater number of funded summer programs, extend training beyond 2 summers, provision for 5-year grants so an additional cohort can be included) would be highly beneficial.

Voting

5 net votes
11 up votes
6 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Improve patient compliance through community health workers

What are effective strategies for community-based participatory dissemination and implementation research initiatives in rural settings?

• Limited number of studies that adapt evidence- or practice-based interventions to rural settings
• Needs innovative approaches to engaging the rural community
• New intervention approaches needs testing in rural communities
• Building a team would have to involve of local community... more »

Voting

7 net votes
15 up votes
8 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Animal Models for Translational Research and Drug Development

There is a need to identify and develop suitable animal models (e.g. larger, non-primate animal models) that faithfully predict the outcomes of new medicines and treatments in heart, lung, blood, and sleep (HLBS) disorders prior to human clinical trials.

Voting

73 net votes
92 up votes
19 down votes
Active
(@dstephens)

Goal 3: Advance Translational Research

Advancing Translational Research

Ensuring that basic science is translated into clinical practice is essential. While there have been great strides in ensuring that babies born with congenital heart defects (CHD) are identified and repaired, we know that there are lifelong implications for those with CHDs that require continued follow-up and treatment. As the proportion of those with CHDs as adults continues to outpace the pediatric population, we urge... more »

Voting

2 net votes
4 up votes
2 down votes
Active
(@chintamani.atreya)

Goal 3: Advance Translational Research

Develop alternatives for patients for whom routine red cell transfusion is unavailable or impractical

There is a compelling need to advance research to understand the physiology governing the safety and efficacy of hemoglobin-based oxygen therapeutics functioning outside the red cell.

Voting

8 net votes
13 up votes
5 down votes
Active
(@ckevil)

Goal 2: Reduce Human Disease

Redox regulation of cardiovascular and lung disease through thiols

Redox imbalance as represented by alterations in oxidative versus reductive stresses are well appreciated to occur during nearly all forms of cardiovascular and lung diseases. However, specific molecular mechanisms responsible for these changes remain largely unknown and poorly organized. Study of redox biology principals has revealed that protein cysteine thiols are a unique target for redox posttranslational modifications... more »

Voting

-5 net votes
5 up votes
10 down votes
Active
(@missyophd)

Goal 2: Reduce Human Disease

Celiac and Gluten Sensitivity Research

Celiac disease is estimated to effect at least 1% of the population, is a burden on patients & the medical profession & can result in co-morbidities such as cancer, but awareness low--most patients endure a host of health problems for a lifetime unless they are lucky enough to get an early diagnosis. Gluten sensitivity, which can cause many of the same debilitating symptoms, does not have a test, & is also common in the... more »

Voting

-7 net votes
4 up votes
11 down votes
Active