Goal 3: Advance Translational Research

Challenges for future clinical trials in COPD

There are two broad issues that any future clinical trials in COPD need to seriously consider, that of the challenges of timely and efficient subject recruitment and the need to increase the participation of low to middle income countries that experience a disproportionate burden of COPD in evidence generation. My specific suggestions are as follows:

1) Address the optimal medical management of multiple physical and psychological comorbidities associated with COPD;

2) Improve understanding of the basic science of the connection between psychiatric illnesses and COPD severity/outcome;

3) Take advantage of “natural experiments” in the form of policy changes to study the effects of air pollution on disease progression and exacerbations

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Idea No. 1600