Goal 2: Reduce Human Disease

Close the gap: Why do men die of cardiovascular disease (CVD) at an earlier age than women?

Despite evidence that women face challenges in receiving optimal CVD care, data show that men die at an earlier age than women of CVD. This health disparity remains unexplained and there are no specific interventions to address it.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

A comprehensive T1-T4 initiative is required to explore this health disparity, ranging from epidemiology to basic mechanisms , and to translate that knowledge into specific interventions.

Closing the gap would add ~4 years of life to men, representing a monumental health improvement.

Feasibility and challenges of addressing this CQ or CC

Conceptually this is straightforward since so many data are already available about sex differences in cardiovascular biology. The challenge is to review the information from this frame of reference and with the specific goal of identifying interventions.

Name of idea submitter and other team members who worked on this idea Barry Coller

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Idea No. 1006