Goal 3: Advance Translational Research

Develop Targeted Therapeutics to Treat Venous Thrombosis and Inflammation in Venous Thromboembolism

Venous Thromboembolism (VTE) afflicts nearly a million Americans yearly, has a mortality of 6-12% and has costs of more than $15 billion. Current treatment regimens, systemic anticoagulation and compression stockings, fail patients in multiple ways: risk of major bleeding episodes; failure of clot resolution in up to 50% of patients; failure to prevent the development of post-thrombotic syndrome (PTS) in up to 40% of patients; failure to prevent long-term recurrence (risk of recurrence is 10%/year). The critical challenge is to a develop safe, targeted therapy for VTE that will result in resolution of clot, resolution of post-thrombotic vein wall inflammation, prevent PTS and prevent recurrence.

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Idea No. 1000