Goal 3: Advance Translational Research

Direct Upregulation of Antioxidant Defenses as a Therapeutic Strategy

Clinical trials involving administration of antioxidants such as vitamin C or vitamin E as therapeutic strategies for cardiovascular diseases associated with oxidant stress have proven to be surprisingly disappointing. A particularly attractive alternative approach is direct upregulation of endogenous antioxidant defenses such as NRF2 via dietary approaches. NRF2 is a master antioxidant and cell protective transcription factor that may be involved either directly or indirectly in up to 200 different human diseases. The potential of direct upregulation of this endogenous transcription factor via dietary approaches avoids the well known difficulties associated with drug-based approaches, e.g. undesirable side effects..

Tags (Keywords associated with the idea)


-5 net votes
2 up votes
7 down votes
Idea No. 957