Goal 3: Advance Translational Research

Heart Valve Engineering from Basic Science to Translation

Heart valve disease is third cardiac condition in the U.S.affecting 2.5% of adult population. There are multiple questions with regard to heart valve engineering from basic science to translation. Many unknowns exist related to calcification and its potential mechanisms in transcatheter heart valve (THV), for example, due to stent crimping that can critically affect the valve durability. This is particularly important as the THV technologies are getting more popular and their indication for use is expanding for younger patients. The other compelling area in heart valve engineering is development of self-regenerating or growth-enabled tissue engineered valves. These technologies can revolutionize the future of heart valve related therapies.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Developing self-regenerating heart valves; Does stent-crimping damage prone the valve's leaflet to premature calcification in transcatheter heart valves? what are the basic biological elements and pathways that result in valve calcification? how can we translate the basic science related to heart valve biology into clinically viable technologies that improve patients condition?

Name of idea submitter and other team members who worked on this idea Arash Kheradvar

Tags (Keywords associated with the idea)



5 net votes
15 up votes
10 down votes
Idea No. 581