Goal 3: Advance Translational Research

How can we determine a patient’s risk of a life-threatening aortic dissection?

Even though science and technology has advanced, many of the advancements have not met the critical challenge of making significant changes in patient therapies for improved outcomes and thus have not been able to break through the translational barrier. In today’s world, risk of aortic dissection is still based purely on a crude size measurement. It is true that evidence indicates that aortic root aneurysm above 4.5 – 5 cm have a higher risk of dissection but there have been people with 9 cm aneurysms that have not dissected. Alternatively, there are many people with aortic root sizes smaller than 4.5 cm that have dissected. There is a critical need for biomarkers and identification of risk factors, other than size.

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Idea No. 832