Goal 2: Reduce Human Disease

In pulmonary arterial hypertension (PAH), how can right ventricular function be improved in the setting of increased afterload

Pulmonary arterial hypertension (PAH) is a complex, progressive condition characterized by high blood pressure in the lungs and restriction of flow through the pulmonary arterial system. Significant improvements have been made in medical management with through approved pulmonary vasodilator therapies. However, long-term right ventricular afterload reductions have still not yet been achieved. The process by which the RV remodels to accommodate this increased pressure and progresses to right ventricular failure is not well understood; PAH patients still die from right ventricular failure on average within approximately 8-10 years of diagnosis.

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Idea No. 775