Goal 2: Reduce Human Disease

Influence of the Gut Microbiome on Pulmonary Immunity in HIV-Infected Individuals

It has become increasingly clear that gut microbiota have a tremendous impact on human health and disease. While it is well known that commensal gut bacteria are crucial in maintaining immune homeostasis in the intestine, there is also evidence of indirect effects on the lung. Multiple studies have shown that alterations in gut microbiota can lead to severe defects in pulmonary immune responses and reduced ability to clear common lung pathogens like influenza. It is now well described that HIV infection is associated with dramatic alterations in gut microbiota so understanding the impact of these changes on the lung of HIV-infected individuals who are highly prone to develop and succumb to pulmonary infections, is of paramount importance.

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Idea No. 820