Goal 1: Promote Human Health

Interaction of blood cells with their environment

It is beginning to be known that malignant cells interact with neighboring cells and the course of their malignancy is directed by those cells. It is also known that transplanted stem cells interact with nearby cells and acquire direction of maturation and cell type from those cells. In my experience in unpublished work, the nature of the materials that leukocytes and monocytes have encountered during their apheresis and storage experience may determine whether the cells are capable of target cell lysis or inhibited from recognizing target cells. Thus: what is the optimal handling of such cells? Or what signals do cells receive by contact with foreign surfaces that influences their future function?

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Idea No. 758