Goal 2: Reduce Human Disease

Mechanics of aortic dissection

The mechanical events in the wall leading to aortic dissection are not well described because merely stating that cellular or biopolymer connections have weakened does not predict the path of the rupture through the media or the risk of rupture. Elucidate the mechanical role of substructures such as collagen fibers, elastin sheets, smooth muscle cells and interstitial fluid in the progression of dissection. Study in animal models whether crack propagation in the aortic wall requires circumferential shearing within the wall in conjunction with compression from blood pressure. Focus on crack propagation in the media rather than crack initiation at the intima.

Tags (Keywords associated with the idea)


7 net votes
17 up votes
10 down votes
Idea No. 676