Goal 2: Reduce Human Disease

Mechanisms for sex-specific differences in lung diseases

What molecular and cellular pathways explain the sex-specific differences in the prevalence, severity, and progression of lung diseases?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Understanding the molecular and cellular bases of differences in prevalence and outcomes of lung diseases will offer insight into disease mechanisms and help to address disease disparities. Some potential bases for disparities, such as differences in hormone levels between men and women, could potentially be therapeutically modulated to mitigate the effects of disease.

Feasibility and challenges of addressing this CQ or CC

The increased understanding of lung cell biology, along with a renewed focus on sex and gender differences, make this the perfect time to start addressing these questions.
Multiple diseases affecting the lung, such as LAM (lymphangioleiomyomatosis), sarcoidosis, asthma, and COPD, have distinct prevalence or associated mortality in a sex-dependent manner. The reasons for these differences are still unknown.

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Idea No. 54