Goal 2: Reduce Human Disease

Modulation of cardiac contraction and relaxation in heart failure: role of systemic inflammation

Is cardiac contraction and relaxation in heart failure modulated by the systemic inflammatory response?

 

There is overwhelming evidence that inflammatory biomarkers predict worse outcome in acute and chronic heart failure.

 

Despite the wealth of evidence, clinical trials in this area have either not been completed, failed, or provided inconclusive results.

 

The questions that remain are:

1) Is inflammation a mechanism of disease in acute or chronic heart failure?

2) Are there viable targets in the inflammatory cascade that can modulate cardiac contraction and relaxation? and can this be achieved without deleterious off-target effects?

3) Can inflammatory biomarkers serve as surrogate endpoints in patients with heart failure?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Addressing this question may fill a decades-old gap in our understanding of the role of inflammation in heart failure, and potentially lead to novel prognostic biomarkers and/or improved therapeutics.

Feasibility and challenges of addressing this CQ or CC

All the preclinical and clinical tools are available.

Name of idea submitter and other team members who worked on this idea Antonio Abbate

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Idea No. 628