Goal 2: Reduce Human Disease

Molecular mechanism for hypertension and the diverse co-morbidities

What molecular mechanism causes hypertension as well as the diverse co-morbidities in hypertension?


We discovered a fundamental mechanism that causes chronic and acute tissue injury due to the action of the powerful digestive enzymes, the same used for daily digestion. In various acute and chronic cardiovascular conditions the compartmentalization of these enzymes fails and they escape into the intestine and systemic circulation where they start an “autodigestion” process with generation of hypertension and many co-morbidities among many other complications.


What are the mechanisms that allow digestive enzymes to escape from their compartmentalization in the pancreatic ducts and small intestine under chronic and acute conditions?

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Idea No. 997