Goal 2: Reduce Human Disease

Prevent cytopenia in septic patients

Sepsis is the leading cause of death in critically ill patients in the USA, affecting particularly young children and the elderly. A hallmark of septic shock patients upon diagnosis is peripheral blood cytopenia. This persistent cytopenia commonly affects myeloid, lymphoid and erythroid lineages resulting in immunosuppression and is a well-established predictor of fatal outcome. Clinical trials targeting the production of inflammatory cytokines during sepsis have been largely unsuccessful, highlighting the need to study novel mechanisms of disease. Understanding how pathogen virulence factors, host genetics and comorbidities contribute to the profound loss of hematopoietic cells will be critical to improve patient outcome.

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Idea No. 705