Goal 2: Reduce Human Disease

Rare Lung Diseases/Sarcoidosis

To conduct longitudinal gene expression analysis of adaptive immunophenotypes within newly-diagnosed sarcoidosis subjects who spontaneously resolve their pulmonary disease compared to those to experience disease progression.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

As you know, sarcoidosis is a granulomatous disease of unknown etiology, characterized by disparate clinical outcomes. Its pathogenesis is a multifactorial process, characterized by dysregulation of T lymphocyte function and Th-1 cytokine expression. Systemic defects in IL-2 and IFNy expression in sarcoidosis have been well-described" 2 Reductions in the cytokine IL-2 and its mediator, lymphocyte-specific protein tyrosine kinase (p56Lck), correlate with disease severity", Also, CD4+ and CD8+ T cells, as well as B cell lymphopenia is associated with disease severity", These observations are particularly important because loss of adaptive immunity and reduced Lck expression has been associated with disease progression among granulomatous disease.

Name of idea submitter and other team members who worked on this idea ATS Member

Tags (Keywords associated with the idea)


3 net votes
3 up votes
0 down votes
Idea No. 1544