Goal 2: Reduce Human Disease

Rare Lung Diseases/Sarcoidosis

To conduct longitudinal gene expression analysis of adaptive immunophenotypes within newly-diagnosed sarcoidosis subjects who spontaneously resolve their pulmonary disease compared to those to experience disease progression.

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As you know, sarcoidosis is a granulomatous disease of unknown etiology, characterized by disparate clinical outcomes. Its pathogenesis is a multifactorial process, characterized by dysregulation of T lymphocyte function and Th-1 cytokine expression. Systemic defects in IL-2 and IFNy expression in sarcoidosis have been well-described" 2 Reductions in the cytokine IL-2 and its mediator, lymphocyte-specific protein tyrosine kinase (p56Lck), correlate with disease severity", Also, CD4+ and CD8+ T cells, as well as B cell lymphopenia is associated with disease severity", These observations are particularly important because loss of adaptive immunity and reduced Lck expression has been associated with disease progression among granulomatous disease.

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Idea No. 1544