Signaling in AVM Developmoent
BMP9 circulates in the blood and signals through the endothelial cell. IN the absence of Alk 1, such as in HHT, the vessels become over-active. The overactivity can be partially balanced by activation of a second signaling pathway: notch. Would targeting notch be a useful drug target to reverse AVM formation
Voting
1
net vote
1
up votes
0
down votes
Active
Idea No. 1081