Goal 1: Promote Human Health

Transformative Impact of Proteomics

The proteomics field has dramatically progressed over the past 20 years, with advancements and improvements in experimental designs and sample preparation protocols, as well as mass spectrometry equipment, approaches, and analysis. This has resulted in substantial forward progress towards a proteomic pipeline to establish cause and effect mechanisms of cardiovascular disease. There is a need for CV proteomics that resolve protein topology to accelerate membrane protein analysis, identify protein-protein interactions, better understand the role of the extracellular environment, and elucidate signaling networks in play over the spatial and time continuums of CV disease processes.

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Idea No. 570