Goal 2: Reduce Human Disease

Transplant to Cure Older Adults with Hematologic Malignancy-Removing the Blindfold

While transplant for patients 60 and older for high-risk hematologic malignancies has increased and observational data are promising, the risks and benefits of translant versus non-transplant remain largely unknown. We now have the tools and mechanisms to remove the blindfold!

 

The NHLBI should support the cooperative groups in conjunction with the BMT-CTN to establish a common framework for transplant trials in older patients, especially for AML, MDS and ALL.This can be done by randomization, donor/no donor, or comparative effectiveness and must include core measures of health (comorbidity, function), baseline disease measures and patient centered outcomes. The framework can apply across studies of typical diseases.

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Idea No. 685