Goal 2: Reduce Human Disease

Understanding Glymphatic Pathways and Waste Clearance abnormalities in brain disease

Cerbrospinal fluid flow and waste clearance through glyphatic pathways are likely to be important in numerous brain diseases including such devastating diseases such as alzheimer's , parkinson's, stroke and migraine. However, relatively little is known about the brain's waste clearance mechanisms, and how failure in these systems may underlie brain disease. Build up of proteins and calcification have been shown to lead to disease, and no doubt herald failure in waste clearance mechanisms, but virtually nothing is known about these systems. Intensive research aimed at understanding regulation of cerebrospinal fluid composition, choroid plexus health, and waste clearance in the brain is sorely needed.

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Idea No. 1133