Goal 2: Reduce Human Disease

Understanding Pathobiology of Exacerbations

COPD exacerbations contribute to poor quality of life, lung function and functional decline. In addition, they are costly to the patient and to health care cost. However, they remain defined exclusively on symptoms and constitute a “soft” endpoint. Actually, the number of exacerbations has become the GOLD standard to establish the risk of outcome (exacerbations). However, a mild episode that only requires outpatient treatment sometimes. There is enough evidence that certain serum markers such as SPD, CC-10, SAA, CRP and IL-6 could be explored as markers of COPD exacerbations and relate their levels to the intermediate outcome such as its relationship to ultimate level of care and development of respiratory failure.

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Idea No. 1583